DEVELOPMENT OF JINDAMANEE MEDICINE PRODUCTION USING MODERN DRUG PRODUCTION MODEL

Abstract

Jindamanee is an ancient traditional Thai herbal formula that has been passed down since the Ayutthaya period. It was originally developed by Somdet Phra Phanarat. It is believed to be a panacea, capable of treating various serious illnesses, including those believed to be caused by bad karma. This study aimed to: Develop the Jindamanee formula into tablet form, develop a modern production process for Jindamanee tablets, and investigate the physical properties of the tablets in comparison with the pharmaceutical standards for tablet production. Six formulas were studied. The extraction of 1.43 kilograms of Jindamanee yielded 29.37% or approximately 420 grams. Upon tablet compression, six formulas were tested. It was found that formula 6 showed higher weights variable more than 7.5% which is above the standard 13.24% respectively. However, all formulas passed the thickness test and formula 2-3 showed the most consistent thicknesses were showed 5.37±0.07 and 5.44±0.27 respectively. Tablet hardness results indicated that formula 1 had the highest average hardness at 3.63±2.37 kp however all formulas doesn’t pass tablet standard. All formulas passed the friability standard test, with formula 6 showing the lowest friability at 0.63%. The disintegration times for all formulas were within acceptable limits, with formula 2 performing best, disintegrating within 2±2.44 minutes. In conclusion, the next study focuses on developing a formula using modern technology and studying the stability of the compounds in Jindamanee medicine.